武汉费斯德生物科技有限公司, NewEast Biosciences 中国办事处
武汉费斯德生物科技有限公司是美国NewEast Biosciences在中国的办事处。NewEast Biosciences 在十二年前率先研发俩种独特的抗体。这俩种抗体仅仅识别活性的GTP酶或者突变的Oncogene。 GTP酶涉及(1)响应细胞表面受体激活的信号转导,包括跨膜受体,例如介导味觉、嗅觉和视觉的那些,(2)核糖体的蛋白质生物合成,(3)调节细胞分化、增殖、分裂和运动,(4)蛋白质通过膜的易位,(5)细胞内囊泡的运输,以及囊泡介导的分泌和摄取,通过GTP酶控制囊泡外壳组装。Oncogene侧是诱发癌症的基因。
我公司将向你提供以下的独一无二的三种抗体或者试剂盒: (1) 仅识别 GTP酶的活性构型的产品, 它可以让你能够量化GTP酶在细胞中的活性和分布。(2) 识别突变 Oncogene蛋白, 但不认识相应野生型的抗体。 (3) 对 cAMP 和 cGMP 具有超亲和力(无需乙酰化)ELISA检测试剂盒。这些产品被将近一千篇同行评议的文章所引用。
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GTPases are generally thought to be active when bound to GTP and inactive when bound to GDP, cycling between these two states regulated by two opposing protein families: guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). These are essential in dissociating tightly bound GDP from GTPases and promoting hydrolysis of GTP, respectively. Our Mouse Monoclonal Antibodies for GTP-bound G Proteins only recognize the active GTP-bound configuration, not inactive GDP-bound state. They have been used to monitor the activation of G protein in cells and in tissues by immunohistochemistry. The RAS superfamily of small GTPases. The 153 members of the RAS superfamily have been classified into five families based on sequence identify and cellular functions (Wennerberg et al. 2005; Wittinghofer and Vetter 2011). Representative members of each family and the main cellular functions are shown. ![]() |